Frequently asked questions about Ovarian Cancer…

Frequently Asked Questions

Ovarian Cancer Myths

Does promoting ovarian cancer information increase anxiety among women?

A recent scientific study in Britain dispelled this idea; promoting cancer information really reassures the public. (British Medical Journal 1999) It is important to empower women with the knowledge to take charge of their health and be good advocates for themselves.

Is it true that a woman who has had her ovaries removed cannot get ovarian cancer?

Technically, women who have their ovaries removed cannot get ovarian cancer. There is a rare type of cancer called primary peritoneal carcinoma – a close relative to ovarian cancer that can develop without the ovaries.

Does ovarian cancer have symptoms in its early stages?

While the symptoms for ovarian cancer tend to be nonspecific and can mimic nongynecologic conditions, a large national study shows that an overwhelming majority of women diagnosed with ovarian cancer did have symptoms, sometimes even in the early stages. The most common symptoms reported include: abdominal bloating or discomfort; increased abdominal size or clothes that fit tighter around your waist; increased or urgent need to urinate and pelvic pain. Additional signs and symptoms are: Persistent gas, indigestion or nausea; unexplained changes in bowel habits; unexplained weight loss or gain; loss of appetite; feeling full quickly during or after a meal and pain during sexual intercourse; a persistent lack of energy, low back pain and shortness of breath.

Source: A. Goff, M.D., Lynn Mandel, Ph.D., Howard G. Muntz, M.D., Cindy H. Melancon, R.N., M.N. 2000. Ovarian carcinoma diagnosis. Cancer 89, No. 10: 1097-0142

Prevention, Risk and Hereditary Factors

Is there an association between Hormone Replacement Therapy and ovarian cancer?

The latest interpretation of data resulting from the Women’s Health Initiative study suggests that postmenopausal women who take combined hormone replacement therapy (HRT) continuously may face a higher risk of ovarian cancer. While researchers say the findings shouldn’t affect most women’s decisions to take HRT to relieve moderate to severe menopausal symptoms, such as hot flashes, the possibility of an increased ovarian cancer risk support recently revised guidelines that call for the conservative use of hormone therapy.

Source: Anderson, G. The Journal of the American Medical Association (Vol 290:1739-1748).

Does the use of talc (talcum powder) as a feminine powder increases the risk of ovarian cancer?

A number of past studies found an increased risk of ovarian cancer from talcum powder use, but these studies were considered inconclusive because of limitations in the way data were collected and analyzed. More recent studies, such as one using data from Harvard University’s Nurses’ Health Study in 2000, find no overall risk of ovarian cancer from talc use and only a modest increase in one type of the disease – invasive serous ovarian cancer.

Source: Journal of the National Cancer Institute (Vol. 92, No. 3).

If a family member has ovarian cancer, can genetic screening determine if other family members will get the disease?

Approximately one out of every ten ovarian cancer cases is hereditary.

Most hereditary ovarian cancer can be attributed to two genes, BRCA 1 (breast cancer gene 1) and BRCA2 (breast cancer gene 2). Women who inherit a mutation in these genes are at greater risk of developing epithelial ovarian cancer.

A thorough evaluation of family history (i.e., a history of breast, colon, or ovarian cancer) can identify women most likely to have a hereditary cancer risk, and genetic testing can determine if these mutations exist. Although having these mutations increases risk, it does not mean a woman will definitely get the disease . Furthermore, while genetic testing can indicate where there is increased risk and help determine appropriate monitoring, women should consider the psychological and possible insurance ramifications before proceeding with testing. Experts suggest that all genetic testing be done in conjunction with genetic counseling.

Source: Cancer Control, July, 1999; Genet Test, 2000.

Is there any way to prevent ovarian cancer?

Currently there is no way of preventing ovarian cancer.

There are, however, several measures that have been found to reduce a woman’s risk of developing the disease. Oral contraceptives can reduce the risk of ovarian cancer by fifty percent if taken for at least five years. Research has also shown that pregnancy and breast-feeding significantly reduce ovarian cancer risk. (Br. J. Cancer, March, 2001).

Tubal ligation and hysterectomy reduce risk, though researchers are unclear exactly how. Finally, prophylactic oophorectomy (removal of the ovaries) also reduces the risk. (Gynecologic Cancer Foundation Slide Presentation, 2000). Health professionals recommend that all options be discussed thoroughly with a physician.

What are ovarian cysts?

Ovarian cysts are fluid-filled sacs on the surface of the ovary that are quite common in women during their childbearing years. Most cysts result from the changes in hormone levels that occur during the menstrual cycle and the production and release of eggs from the ovaries. Most are harmless and go away on their own.

What is endometriosis? Can it cause ovarian cancer?

Endometriosis is a chronic and often progressive disease that develops when endometrial tissue, which normally lines the inner surface of the uterus, grows outside of the uterus. These implants occur most frequently in the pelvic region and on the reproductive organs but can appear in other areas, such as the bladder, as well.

In spite of the high prevalence of endometriosis in women the world over, researchers have been unable to determine its cause. Endometriosis can cause pain and scarring, and it is believed that 20 percent to 40 percent of women diagnosed with this chronic disease are infertile. (National Cancer Institute)

Researchers hypothesized that the most likely link between endometriosis and ovarian cancer is the association between endometriosis and infertility. It is well established that ovarian cancer risk is reduced with each pregnancy. Consequently, women who do not bear children, whether by choice or due to infertility issues, are believed to be at greater risk for ovarian cancer. (The Gynecologic Sourcebook, Third Edition)

Do fertility drugs increase your risk of developing ovarian cancer?

Use of fertility drugs does not increase a woman’s risk of getting ovarian cancer. On the other hand, the scientists did find an association between ovarian cancer and certain causes of infertility itself, such as endometriosis.

“Some women who receive fertility treatments develop ovarian cancer because of underlying conditions that cause infertility, not because of the treatments themselves,” said Roberta Ness, MD, MPH, of the University of Pittsburgh’s School of Public Health.

Source: American Journal of Epidemiology (Vol. 155, No. 3: 217-224).

Is there a link between breast cancer and ovarian cancer?

Both breast and ovarian cancer can be caused by mutations in the BRCA1 (breast cancer gene 1) and BRCA2 (breast cancer gene 2) genes. Women with a family history of breast and ovarian cancer, or a personal history for either, particularly if diagnosed before age 50, should be aware of increased risk for the other. Women who have had breast cancer before the age of 50 are twice as likely to develop ovarian cancer, as are women who have not. (National Cancer Institute – What You Need To Know About Ovarian Cancer, 1998). Additionally, ovarian cancer has also been linked to colon cancer (via different genes).

Screening Tools, Detection and Treatment

Does an elevated CA 125 level always indicate that ovarian cancer is present?

Not always. Although a CA 125 blood test can be a useful tool for the diagnosis of ovarian cancer, in premenopausal women, it is not uncommon for a CA 125 count to be elevated due to benign conditions unrelated to ovarian cancer. Uterine fibroids, liver disease, inflammation of the fallopian tubes and other types of cancer can elevate a woman’s CA 125 level. (ACOG Patient Education – 1996) The CA 125 test is more accurate in postmenopausal women. It is also important to note that in about 20% of cases of advanced stage disease, and 50% of cases of early stage disease, the CA 125 is NOT elevated, even though there is ovarian cancer present. As a result, the CA 125 is generally only one of several tools used to diagnose ovarian cancer. One of the most important uses of the CA 125 test, however, is to evaluate progressive disease and tumor response in patients undergoing treatment, and to monitor the levels of women in remission for evidence of disease recurrence.

What is a clinical trial?

Clinical trials are carefully designed research studies that involve people. Some clinical trials are conducted to find ways to improve the medical care and treatment that is available to women with ovarian cancer. Some trials test ways to detect and prevent ovarian cancer or its recurrence. There are also clinical trials that study how to improve an ovarian cancer patient’s quality of life during and after treatment.

Is the blood marker LPA (lysophosphatidic acid) an effective screening tool for ovarian cancer?

LPA or lysophosphatidic acid is a substance that stimulates the growth of ovarian tumors. One small study found that levels of LPA in blood plasma are elevated in about 90% of women with early ovarian cancer. There are clinical trials going on presently to determine the effectiveness of LPA in detecting ovarian cancer. (JAMA, August 26, 1998) However, it is still to early to know if this test will be a good screening tool. This test is not yet available to the public.

Who is best trained to treat ovarian cancer?

Gynecologic oncologists. Research has shown that the five-year survival rate is greater when the initial surgery is performed by a gynecologic oncologist. (NCI) The initial surgery and staging of ovarian cancer is critical to determining the appropriate course of treatment, and ultimately survival outcomes. A gynecologic oncologist is an obstetrician gynecologist who is further trained in oncology to specialize in the diagnosis and treatment of women with gynecologic cancers. To find a gynecologic oncologist in your area, visit the Women’s Cancer Network website at www.wcn.org and select “Find a Doc,” or call 1-800-444-4441.

If there are no accurate screening tools, how is ovarian cancer diagnosed?

An exploratory surgical procedure called laparotomy is generally required for the definitive diagnosis of ovarian cancer. During this procedure, cysts or other suspicious areas must be removed and biopsied. After the incision is made, the surgeon assesses the fluid and cells in the abdominal cavity. If the lesion is cancerous, the surgeon continues with a process called surgical staging to ascertain how far the cancer has spread.

“Ovarian cancer is more than a woman’s disease. ….”

What is Ovarian Cancer?

Ovarian cancer is a disease in which malignant or cancerous cells are found in the ovaries. An ovary is one of two small, almond-shaped organs located on each side of the uterus that store eggs or germ cells and produce female hormones estrogen and progesterone.

Cancer Basics

Cancer develops when cells in a part of the body (in this case the ovary) begin to grow out of control. Although there are many kinds of cancer, they all start because of out-of-control growth of abnormal cells.

Normally, cells in your body divide, and form new cells to replace worn out or dying cells and to repair injuries. Because cancer cells continue to grow and divide, they are different from normal cells. Instead of dying, they outlive normal cells and continue to create new abnormal cells forming a tumor. Tumors can put pressure on other organs lying near the ovaries.

Cancer cells sometimes can travel to other parts of the body where they begin to grow and replace normal tissue. This process, called metastasis, occurs as the cancer cells move into the bloodstream or lymph vessels of our body. Cancer cells that spread from other organ sites (such as breast or colon) to the ovary are not considered ovarian cancer

There are many types of tumors that can start in the ovaries. Some are benign, or noncancerous, and the patient can be cured by surgically removing one ovary or the part of the ovary containing the tumor. Some are malignant or cancerous. The treatment options and the outcome for the patient depend on the type of ovarian cancer and how far it has spread before it is diagnosed.

What is the general outlook for women diagnosed with ovarian cancer?

In women age 35-74, ovarian cancer is the fifth leading cause of cancer-related deaths. An estimated one woman in 71 will develop ovarian cancer during her lifetime. The American Cancer Society estimates that there will be over 22,000 new cases of ovarian cancer diagnosed this year and that more than 15,000 women will die from ovarian cancer this year.

When one is diagnosed and treated in the earliest stages, the 5-year survival rate is over 90%. Due to ovarian cancer’s non-specific symptoms and lack of early detection tests, only 19% of all cases are found at this early stage. If caught in stage III or higher, the survival rate can be as low as 30.6%. Due to the nature of the disease, each woman diagnosed with ovarian cancer has a different profile and it is impossible to provide a general prognosis.

Source: American Cancer Society